Increased activation of frontal areas during arm movement in idiopathic torsion dystonia
Identifieur interne : 004F81 ( Main/Exploration ); précédent : 004F80; suivant : 004F82Increased activation of frontal areas during arm movement in idiopathic torsion dystonia
Auteurs : Diane Playford [Royaume-Uni] ; Richard E. Passingham [Royaume-Uni] ; C. David Marsden [Royaume-Uni] ; David J. Brooks [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1998-03.
English descriptors
- KwdEn :
- Adult, Attention (physiology), Brain Mapping, Cerebellum (blood supply), Cerebellum (physiopathology), Cerebral blood flow, Dominance, Cerebral (physiology), Dystonia Musculorum Deformans (diagnosis), Dystonia Musculorum Deformans (physiopathology), Female, Frontal Lobe (blood supply), Frontal Lobe (physiopathology), Functional Laterality (physiology), Gyrus Cinguli (blood supply), Gyrus Cinguli (physiopathology), Humans, Idiopathic torsion dystonia, Male, Middle Aged, Motor Cortex (blood supply), Motor Cortex (physiopathology), Neurologic Examination, Positron emission tomography, Prefrontal Cortex (blood supply), Prefrontal Cortex (physiopathology), Psychomotor Performance (physiology), Putamen (blood supply), Putamen (physiopathology), Regional Blood Flow (physiology).
- MESH :
- blood supply : Cerebellum, Frontal Lobe, Gyrus Cinguli, Motor Cortex, Prefrontal Cortex, Putamen.
- diagnosis : Dystonia Musculorum Deformans.
- physiology : Attention, Dominance, Cerebral, Functional Laterality, Psychomotor Performance, Regional Blood Flow.
- physiopathology : Cerebellum, Dystonia Musculorum Deformans, Frontal Lobe, Gyrus Cinguli, Motor Cortex, Prefrontal Cortex, Putamen.
- Adult, Brain Mapping, Female, Humans, Male, Middle Aged, Neurologic Examination.
Abstract
Most positron emission tomography (PET) studies of regional cerebral function in idiopathic torsion dystonia (ITD) have failed to show abnormalities, but there have been few studies of the changes in regional cerebral blood flow (rCBF) that occur during movement in dystonia. Using PET, we have studied six patients with familial generalized ITD both at rest and while moving a joystick with the right hand. The patterns of CBF change obtained were compared with those in six age‐matched control subjects. In the dystonia group, free selection of movement was associated with relative increases in rCBF above that observed in control subjects in the left premotor area, the supplementary motor area (SMA), the anterior cingulate cortex, and the left dorsolateral prefrontal area. Subcortical increases were observed within the cerebellum and the putamen. There was a relative decrease in flow through the contralateral primary sensorimotor cortex. These findings contrast with those reported in patients with Parkinson's disease undertaking the same task in which the activity in the SMA and putamen was decreased. We suggest that arm dystonia in ITD is associated with overactivity of the premotor areas, including the SMA, and that this results from release of the thalamus from the normal inhibitory influence of the globus pallidus internal segment. Other abnormalities of basal ganglia control of brain stem centers may be involved in axial dystonia.
Url:
DOI: 10.1002/mds.870130218
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000376
- to stream Istex, to step Curation: 000376
- to stream Istex, to step Checkpoint: 003716
- to stream PubMed, to step Corpus: 004466
- to stream PubMed, to step Curation: 004466
- to stream PubMed, to step Checkpoint: 004411
- to stream Ncbi, to step Merge: 004F17
- to stream Ncbi, to step Curation: 004F17
- to stream Ncbi, to step Checkpoint: 004F17
- to stream Main, to step Merge: 007E93
- to stream Main, to step Curation: 004F81
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased activation of frontal areas during arm movement in idiopathic torsion dystonia</title><author><name sortKey="Diane Playford" sort="Diane Playford" uniqKey="Diane Playford" last="Diane Playford">Diane Playford</name></author><author><name sortKey="Passingham, Richard E" sort="Passingham, Richard E" uniqKey="Passingham R" first="Richard E." last="Passingham">Richard E. Passingham</name></author><author><name sortKey="David Marsden, C" sort="David Marsden, C" uniqKey="David Marsden C" first="C." last="David Marsden">C. David Marsden</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0C2B5889D548EB89FF913DE241975E8DD383171F</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1002/mds.870130218</idno><idno type="url">https://api.istex.fr/document/0C2B5889D548EB89FF913DE241975E8DD383171F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000376</idno><idno type="wicri:Area/Istex/Curation">000376</idno><idno type="wicri:Area/Istex/Checkpoint">003716</idno><idno type="wicri:doubleKey">0885-3185:1998:Diane Playford:increased:activation:of</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:9539346</idno><idno type="wicri:Area/PubMed/Corpus">004466</idno><idno type="wicri:Area/PubMed/Curation">004466</idno><idno type="wicri:Area/PubMed/Checkpoint">004411</idno><idno type="wicri:Area/Ncbi/Merge">004F17</idno><idno type="wicri:Area/Ncbi/Curation">004F17</idno><idno type="wicri:Area/Ncbi/Checkpoint">004F17</idno><idno type="wicri:doubleKey">0885-3185:1998:Playford E:increased:activation:of</idno><idno type="wicri:Area/Main/Merge">007E93</idno><idno type="wicri:Area/Main/Curation">004F81</idno><idno type="wicri:Area/Main/Exploration">004F81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Increased activation of frontal areas during arm movement in idiopathic torsion dystonia</title><author><name sortKey="Diane Playford" sort="Diane Playford" uniqKey="Diane Playford" last="Diane Playford">Diane Playford</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>MRC Cyclotron Unit, Hammersmith Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Passingham, Richard E" sort="Passingham, Richard E" uniqKey="Passingham R" first="Richard E." last="Passingham">Richard E. Passingham</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>MRC Cyclotron Unit, Hammersmith Hospital</wicri:orgArea></affiliation><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><wicri:orgArea>Department of Experimental Psychology</wicri:orgArea></affiliation></author><author><name sortKey="David Marsden, C" sort="David Marsden, C" uniqKey="David Marsden C" first="C." last="David Marsden">C. David Marsden</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>MRC Cyclotron Unit, Hammersmith Hospital</wicri:orgArea></affiliation><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>The Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>MRC Cyclotron Unit, Hammersmith Hospital</wicri:orgArea></affiliation><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><wicri:orgArea>Department of Experimental Psychology</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1998-03">1998-03</date><biblScope unit="vol">13</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="309">309</biblScope><biblScope unit="page" to="318">318</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">0C2B5889D548EB89FF913DE241975E8DD383171F</idno><idno type="DOI">10.1002/mds.870130218</idno><idno type="ArticleID">MDS870130218</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Attention (physiology)</term><term>Brain Mapping</term><term>Cerebellum (blood supply)</term><term>Cerebellum (physiopathology)</term><term>Cerebral blood flow</term><term>Dominance, Cerebral (physiology)</term><term>Dystonia Musculorum Deformans (diagnosis)</term><term>Dystonia Musculorum Deformans (physiopathology)</term><term>Female</term><term>Frontal Lobe (blood supply)</term><term>Frontal Lobe (physiopathology)</term><term>Functional Laterality (physiology)</term><term>Gyrus Cinguli (blood supply)</term><term>Gyrus Cinguli (physiopathology)</term><term>Humans</term><term>Idiopathic torsion dystonia</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (blood supply)</term><term>Motor Cortex (physiopathology)</term><term>Neurologic Examination</term><term>Positron emission tomography</term><term>Prefrontal Cortex (blood supply)</term><term>Prefrontal Cortex (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Putamen (blood supply)</term><term>Putamen (physiopathology)</term><term>Regional Blood Flow (physiology)</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Cerebellum</term><term>Frontal Lobe</term><term>Gyrus Cinguli</term><term>Motor Cortex</term><term>Prefrontal Cortex</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonia Musculorum Deformans</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Dominance, Cerebral</term><term>Functional Laterality</term><term>Psychomotor Performance</term><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellum</term><term>Dystonia Musculorum Deformans</term><term>Frontal Lobe</term><term>Gyrus Cinguli</term><term>Motor Cortex</term><term>Prefrontal Cortex</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most positron emission tomography (PET) studies of regional cerebral function in idiopathic torsion dystonia (ITD) have failed to show abnormalities, but there have been few studies of the changes in regional cerebral blood flow (rCBF) that occur during movement in dystonia. Using PET, we have studied six patients with familial generalized ITD both at rest and while moving a joystick with the right hand. The patterns of CBF change obtained were compared with those in six age‐matched control subjects. In the dystonia group, free selection of movement was associated with relative increases in rCBF above that observed in control subjects in the left premotor area, the supplementary motor area (SMA), the anterior cingulate cortex, and the left dorsolateral prefrontal area. Subcortical increases were observed within the cerebellum and the putamen. There was a relative decrease in flow through the contralateral primary sensorimotor cortex. These findings contrast with those reported in patients with Parkinson's disease undertaking the same task in which the activity in the SMA and putamen was decreased. We suggest that arm dystonia in ITD is associated with overactivity of the premotor areas, including the SMA, and that this results from release of the thalamus from the normal inhibitory influence of the globus pallidus internal segment. Other abnormalities of basal ganglia control of brain stem centers may be involved in axial dystonia.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Oxfordshire</li></region><settlement><li>Londres</li><li>Oxford</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Diane Playford" sort="Diane Playford" uniqKey="Diane Playford" last="Diane Playford">Diane Playford</name></region><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><name sortKey="David Marsden, C" sort="David Marsden, C" uniqKey="David Marsden C" first="C." last="David Marsden">C. David Marsden</name><name sortKey="David Marsden, C" sort="David Marsden, C" uniqKey="David Marsden C" first="C." last="David Marsden">C. David Marsden</name><name sortKey="Passingham, Richard E" sort="Passingham, Richard E" uniqKey="Passingham R" first="Richard E." last="Passingham">Richard E. Passingham</name><name sortKey="Passingham, Richard E" sort="Passingham, Richard E" uniqKey="Passingham R" first="Richard E." last="Passingham">Richard E. Passingham</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004F81 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004F81 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:0C2B5889D548EB89FF913DE241975E8DD383171F
|texte= Increased activation of frontal areas during arm movement in idiopathic torsion dystonia
}}
| This area was generated with Dilib version V0.6.23. |  |